Sandbox Reserved 827: Difference between revisions
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But TBK1 can undergo another type of post-translationnal modifications : polyubiquitination. Polyubiquitination in a Lys63 manner on | But TBK1 can undergo another type of post-translationnal modifications : polyubiquitination. Polyubiquitination in a Lys63 manner on | ||
<scene name='56/568025/K30/1'>Lys30</scene> helps the activation of the kinase. The same type of modification on <scene name='56/568025/K401/1'>Lys401</scene> is responsible for dimerization. Type Lys48 polyubiquitination on Lys670 is done by DTX4 and is responsible for the degradation of the protein. | <scene name='56/568025/K30/1'>Lys30</scene> helps the activation of the kinase. The same type of modification on <scene name='56/568025/K401/1'>Lys401</scene> is responsible for dimerization. Type Lys48 polyubiquitination on Lys670 is done by DTX4 and is responsible for the degradation of the protein. | ||
== Diseases == | |||
'''Interaction with viral proteins :''' | |||
TBK1 is the target of some viral proteins such as VP35 from Ebola virus, or the P protein from Borna virus. Those proteins inhibit TBK1. Normally, TBK1 is responsible for virus-induced phosphorylations that lead to the cellular antiviral state. Therefore, the inhibition of the kinase prevents the establishment of such a cellular state. | |||
== References == | |||
Q05127 | |||