4nr8: Difference between revisions
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{{STRUCTURE_4nr8| PDB=4nr8 | SCENE= }} | |||
===Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand=== | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[4nr8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NR8 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Brennan, P.]] | |||
[[Category: Delft, F Von.]] | |||
[[Category: Edwards, A M.]] | |||
[[Category: Fedorov, O.]] | |||
[[Category: Felletar, I.]] | |||
[[Category: Filippakopoulos, P.]] | |||
[[Category: Hay, D.]] | |||
[[Category: Knapp, S.]] | |||
[[Category: Martin, S.]] | |||
[[Category: Picaud, S.]] | |||
[[Category: SGC, Structural Genomics Consortium.]] | |||
[[Category: Chemical tool]] | |||
[[Category: Sgc]] | |||
[[Category: Small molecule inhibitor]] | |||
[[Category: Structural genomics consortium]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription-inhibitor complex]] | |||
Revision as of 13:30, 25 December 2013
Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligandCrystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand
DiseaseDisease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]
FunctionFunction
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this StructureAbout this Structure
4nr8 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0