4npp: Difference between revisions
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{{STRUCTURE_4npp| PDB=4npp | SCENE= }} | |||
===The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | |||
==About this Structure== | |||
[[4npp]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPP OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Changeux, J P.]] | |||
[[Category: Corringer, P J.]] | |||
[[Category: Delarue, M.]] | |||
[[Category: Haouz, A.]] | |||
[[Category: Huon, C.]] | |||
[[Category: Menny, A.]] | |||
[[Category: Nemecz, A.]] | |||
[[Category: Poitevin, F.]] | |||
[[Category: Sauguet, L.]] | |||
[[Category: Shahsavar, A]] | |||
[[Category: Pentameric ligand-gated ion channel]] | |||
[[Category: Ph-gated]] | |||
[[Category: Transmembrane]] | |||
[[Category: Transport protein]] | |||
Revision as of 13:30, 25 December 2013
The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) formsThe GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms
FunctionFunction
[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]
About this StructureAbout this Structure
4npp is a 5 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371