4ne5: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4ne5|  PDB=4ne5  |  SCENE=  }}
+===Human MHF1-MHF2 complex===
-The entry 4ne5 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN]] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8] [[http://www.uniprot.org/uniprot/CENPX_HUMAN CENPX_HUMAN]] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:6]
-Authors: Zhao, Q., Saro, D., Sachpatzidis, A., Sung, P., Xiong, Y.
+==About this Structure==
+[[4ne5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NE5 OCA].
-Description: Human MHF1-MHF2 complex
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Sachpatzidis, A.]]
+[[Category: Saro, D.]]
+[[Category: Sung, P.]]
+[[Category: Xiong, Y.]]
+[[Category: Zhao, Q.]]
+[[Category: Dna binding protein]]
+[[Category: Dna repair]]
+[[Category: Fancm]]
+[[Category: Fanconi anemia]]
+[[Category: Genome maintenance]]
+[[Category: Histone fold]]
+[[Category: Nucleus]]