4lez: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4lez|  PDB=4lez  |  SCENE=  }}
+===Structure of mouse cGAS bound to an 18bp DNA and cGAS product===
-The entry 4lez is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
-Authors: Li, P.
+==About this Structure==
+[[4lez]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEZ OCA].
-Description: Structure of mouse cGAS bound to an 18bp DNA and cGAS product
+[[Category: Li, P.]]
+[[Category: Dna sensor]]
+[[Category: Ntase]]
+[[Category: Transferase-dna complex]]