4kl9: Difference between revisions
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{{STRUCTURE_4kl9| PDB=4kl9 | SCENE= }} | |||
===Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2=== | |||
{{ABSTRACT_PUBMED_24210757}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | |||
[[4kl9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KL9 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024210757</ref><references group="xtra"/><references/> | |||
[[Category: Dihydrofolate reductase]] | |||
[[Category: Blundell, T L.]] | |||
[[Category: Dias, M V.B]] | |||
[[Category: Tyrakis, P.]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Reductase]] | |||
Revision as of 13:17, 25 December 2013
Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in the space group C2
Template:ABSTRACT PUBMED 24210757
FunctionFunction
[DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this StructureAbout this Structure
4kl9 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Dias MV, Tyrakis P, Domingues RR, Leme AF, Blundell TL. Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs. Structure. 2013 Nov 6. pii: S0969-2126(13)00395-X. doi:, 10.1016/j.str.2013.09.022. PMID:24210757 doi:http://dx.doi.org/10.1016/j.str.2013.09.022