4isk: Difference between revisions

Revision as of 13:17, 25 December 2013

[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.

4isk is a 8 chain structure. Full crystallographic information is available from OCA.

↑ Tochowicz A, Dalziel S, Eidam O, O'Connell JD 3rd, Griner S, Finer-Moore JS, Stroud RM. Development and Binding Mode Assessment of N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta [g]quinazolin-6-yl]amino]benzoyl]-l-gamma-glutamyl-d-glutamic Acid (BGC 945), a Novel Thymidylate Synthase Inhibitor That Targets Tumor Cells. J Med Chem. 2013 Jun 21. PMID:23710599 doi:http://dx.doi.org/10.1021/jm400490e

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-'''Unreleased structure'''
+{{STRUCTURE_4isk|  PDB=4isk  |  SCENE=  }}
+===Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor===
+{{ABSTRACT_PUBMED_23710599}}
-The entry 4isk is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
-Authors: Tochowicz, A., Finer-Moore, J., Stroud, R.M.
+==About this Structure==
+[[4isk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISK OCA].
-Description: Crystal structure of E.coli thymidylate synthase with dUMP and the BGC 945 inhibitor
+==Reference==
+<ref group="xtra">PMID:023710599</ref><references group="xtra"/><references/>
+[[Category: Thymidylate synthase]]
+[[Category: Finer-Moore, J.]]
+[[Category: Stroud, R M.]]
+[[Category: Tochowicz, A.]]
+[[Category: Alpha/beta protein]]
+[[Category: Dump subtrate]]
+[[Category: Methylase]]
+[[Category: Methyltransferase]]
+[[Category: Transferase-transferase inhibitor complex]]