4lh7: Difference between revisions
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{{STRUCTURE_4lh7| PDB=4lh7 | SCENE= }} | |||
===Crystal structure of a LigA inhibitor=== | |||
{{ABSTRACT_PUBMED_24287382}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity). | |||
==About this Structure== | |||
[[4lh7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH7 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024287382</ref><references group="xtra"/><references/> | |||
[[Category: Boriack-Sjodin, P A.]] | |||
[[Category: Prince, D B.]] | |||
[[Category: Ligase-ligase inhibitor complex]] | |||
[[Category: Protein-inhibitor complex]] | |||
Revision as of 13:14, 25 December 2013
Crystal structure of a LigA inhibitorCrystal structure of a LigA inhibitor
Template:ABSTRACT PUBMED 24287382
FunctionFunction
[DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
About this StructureAbout this Structure
4lh7 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Murphy-Benenato K, Wang H, McGuire HM, Davis HE, Gao N, Prince DB, Jahic H, Stokes SS, Boriack-Sjodin PA. Identification through structure-based methods of a bacterial NAD-dependent DNA ligase inhibitor that avoids known resistance mutations. Bioorg Med Chem Lett. 2013 Nov 15. pii: S0960-894X(13)01286-9. doi:, 10.1016/j.bmcl.2013.11.007. PMID:24287382 doi:http://dx.doi.org/10.1016/j.bmcl.2013.11.007