4nm8: Difference between revisions
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{{STRUCTURE_4nm8| PDB=4nm8 | SCENE= }} | |||
===Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin=== | |||
{{ABSTRACT_PUBMED_24335589}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity). | |||
==About this Structure== | |||
[[4nm8]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM8 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024335589</ref><references group="xtra"/><references/> | |||
[[Category: Lee, P S.]] | |||
[[Category: Wilson, I A.]] | |||
[[Category: Immune recognition]] | |||
[[Category: Immunoglobulin]] | |||
[[Category: Immunoglobulins']] | |||
[[Category: Viral fusion protein]] | |||
[[Category: Viral protein-immune system complex]] | |||
[[Category: Virus attachment and entry]] | |||
Revision as of 13:13, 25 December 2013
Crystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutininCrystal structure of broadly neutralizing antibody CR8043 bound to H3 influenza hemagglutinin
Template:ABSTRACT PUBMED 24335589
FunctionFunction
[HEMA_I68A4] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
About this StructureAbout this Structure
4nm8 is a 12 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, Bakker AQ, Beaumont T, Spits H, Kwaks T, Vogels R, Ward AB, Goudsmit J, Wilson IA. A common solution to group 2 influenza virus neutralization. Proc Natl Acad Sci U S A. 2013 Dec 11. PMID:24335589 doi:http://dx.doi.org/10.1073/pnas.1319058110