3qi1: Difference between revisions

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-[[Image:3qi1.jpg|left|200px]]
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 {{STRUCTURE_3qi1|  PDB=3qi1  |  SCENE=  }}
 ===Design and synthesis of hydroxyethylamine (hea) BACE-1 inhibitors: prime side chromane-containing inhibitors===
+{{ABSTRACT_PUBMED_23856050}}
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 ==About this Structure==
-[[3qi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI1 OCA].
+[[3qi1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI1 OCA].
-[[Category: Homo sapiens]]
+==See Also==
+*[[Beta secretase|Beta secretase]]
+==Reference==
+<ref group="xtra">PMID:023856050</ref><references group="xtra"/><references/>
+[[Category: Human]]
 [[Category: Memapsin 2]]
 [[Category: Yao, N.]]
 [[Category: Aspartate protease]]
 [[Category: Hydrolase-hydrolase inhibitor complex]]