Molecular Playground/Bacterial Chemotaxis Complex: Difference between revisions

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• The <scene name='57/571407/Cytoplasmic_receptor/1'>chemoreceptor</scene> (1QU7) – also called methyl-accepting protein, MCP – is a ~380Å long, alpha helical homo-dimer with many domains. The <scene name='57/571407/Cytoplasmic_receptor/2'>signaling domain</scene> at the cytosplasmic tip is where both CheW and CheA interact and bind.  
• The <scene name='57/571407/Cytoplasmic_receptor/1'>chemoreceptor</scene> (1QU7) – also called methyl-accepting protein, MCP – is a ~380Å long, alpha helical homo-dimer with many domains. The <scene name='57/571407/Cytoplasmic_receptor/2'>signaling domain</scene> at the cytosplasmic tip is where both CheW and CheA interact and bind.  


• <scene name='57/571407/Chea_p3p4p5/1'>CheA</scene> (1B3Q shows P3-P5 as a homodimer) is a large 5-subdomain (P1-P5) histidine kinase that auto-phosphorylates depending on it's interaction with the receptor and localized concentrations of the response regulator protein CheY.
• <scene name='57/571407/Chea_p3p4p5/1'>CheA</scene> is a large 5-subdomain (P1-P5) histidine kinase that auto-phosphorylates depending on it's interaction with the receptor and localized concentrations of the response regulator protein CheY. This scene is of P3-P5 as a homo-dimer (1B3Q). For more information, see [http://proteopedia.org/wiki/index.php/Molecular_Playground/CheA CheA Molecular Playground page]

Revision as of 23:59, 16 December 2013

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A single asymmetric unit ternary complex with the truncated receptor, CheA, and CheW 3UR1

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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst.

Bacterial chemotaxis is a method for cells to sense and adapt to chemicals in their environment. It is carried out by large arrays of membrane associated multi-protein complexes that form at the poles of the cells. The major players involved are the transmembrane receptor, histidine kinase CheA, and scaffold/adaptor protein CheW. Repellants and attractants bind to the periplasmic domain of the receptor. The signal is then relayed within the cytoplasm to govern CheA's kinase activity, and ultimately lead to changes in swimming behavior.

StructureStructure

• The (1QU7) – also called methyl-accepting protein, MCP – is a ~380Å long, alpha helical homo-dimer with many domains. The at the cytosplasmic tip is where both CheW and CheA interact and bind.

• is a large 5-subdomain (P1-P5) histidine kinase that auto-phosphorylates depending on it's interaction with the receptor and localized concentrations of the response regulator protein CheY. This scene is of P3-P5 as a homo-dimer (1B3Q). For more information, see CheA Molecular Playground page

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Elizabeth R. Haglin, Michal Harel, Maryam Kashefy
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