Pseudoenzyme: Difference between revisions
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[[Pseudoenzyme|Pseudoenzymes]] are proteins that cannot catalyze chemical reactions despite being clearly related structurally to functioning enzymes. Many enzyme families contain inactive members. For example, a number of human kinases lack at least one of the key amino acids necessary for catalysis of phosphate transfer. Often [[Pseudoenzyme|pseudoenzymes]] still have biological roles, albeit non-catalytic. Some assist true enzymes in obtaining functional folds, some server as platforms for other proteins to interact, and some are escorts for proteins <ref>PMID: 23559232</ref><ref>PMID: 23559233</ref>. | [[Pseudoenzyme|Pseudoenzymes]] are proteins that cannot catalyze chemical reactions despite being clearly related structurally to functioning enzymes. Many enzyme families contain inactive members. For example, a number of human kinases lack at least one of the key amino acids necessary for catalysis of phosphate transfer. Often [[Pseudoenzyme|pseudoenzymes]] still have biological roles, albeit non-catalytic. Some assist true enzymes in obtaining functional folds, some server as platforms for other proteins to interact, and some are escorts for proteins <ref>PMID: 23559232</ref><ref>PMID: 23559233</ref>. | ||