Interleukin: Difference between revisions
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{{STRUCTURE_2nvh| PDB=2nvh | SIZE=400| SCENE= |right| CAPTION=Human interleukin-1 β chain complex with sulfate, [[2nvh]] }} | {{STRUCTURE_2nvh| PDB=2nvh | SIZE=400| SCENE= |right| CAPTION=Human interleukin-1 β chain complex with sulfate, [[2nvh]] }} | ||
'''Interleukin''' (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers. | '''Interleukin''' (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.<br /> | ||
* IL-1 is a group of 11 cytokines which regulate immune and inflammatory response.<br /> | |||
* IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.<br /> | |||
* IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.<br /> | |||
* IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | |||
* IL-5 stimulates B cell growth and increases immunoglobulin secretion.<br /> | |||
* IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.<br /> | |||
* IL-7 is a cytokine important for B and T cells development.<br /> | |||
* IL-8 induces chemotaxis and phagocytosis.<br /> | |||
* IL-10 see [[Interleukin-10]].<br /> | |||
* IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br /> | |||
* IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | |||
* IL-15 see [[Interleukin-15]].<br /> | |||
* IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.<br /> | |||
* IL-17 recruits monocytes and neutrophils to the site of inflammation.<br /> | |||
* IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br /> | |||
* IL-19 induces activation of the signal transducer and activator of STAT3.<br /> | |||
* IL-21 has potent effect on natural killer cells.<br /> | |||
* IL-22 stimulates inflammatory responses like S100 and defensin.<br /> | |||
* IL-23 induces activation of the signal transducer and activator of STAT4.<br /> | |||
* IL-28 has a role in the immune defense against viruses.<br /> | |||
* IL-29 similar to IL-28.<br /> | |||
* IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br /> | |||
* IL-34 increases growth or survival of monocytes.<br /> | |||
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