Succinate Dehydrogenase: Difference between revisions
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<StructureSection load='3ae1' size='500' side='right' caption='Succinate dehydrogenase containing flavoprotein subunit (grey), iron-sulfur subunit (green), cytochrome B560 subunit (pink) and cytochrome B small subunit (yellow), FAD, Fe2S2, Fe4S4 and Fe3S4 complex with protoporphyrin, malonate, benzamide derivative and α-phosphatidyl-β-oleoyl-γ-palmitoyl-phosphatidylethanolamine, [[3ae1]] ' scene=''> | <StructureSection load='3ae1' size='500' side='right' caption='Succinate dehydrogenase containing flavoprotein subunit (Sdha) (grey), iron-sulfur subunit (Sdhb) (green), cytochrome B560 subunit (Sdhc) (pink) and cytochrome B small subunit (Sdhd) (yellow), FAD, Fe2S2, Fe4S4 and Fe3S4 complex with protoporphyrin, malonate, benzamide derivative and α-phosphatidyl-β-oleoyl-γ-palmitoyl-phosphatidylethanolamine, [[3ae1]] ' scene=''> | ||
[[Image:Succinate Dehydrogenase.png|left|250px]][[Succinate Dehydrogenase]] (PDB = [[2wdv]] with empty ubiquinone binding site; PDB = [[1nek]] with ubiquinone bound), also called '''succinate-coenzyme Q reductase''' (SQR) or '''Complex II''', is a tetrameric enzyme found in the cell membrane of some bacteria and the inner mitochondrial membrane of mammalian cells. It is classified as an α+β protein, as it contains <scene name='Michael_Vick_Sandbox_2/2wdv_sec_structure/1'>segregated regions</scene> of α helices and antiparallel β sheets. It is involved in two aspects of digestion; it catalyzes the oxidation of succinate to fumarate in the [[The_Citric_Acid_Cycle|citric acid cycle]] by simultaneously reducing ubiquinone to ubiquinol in the electron transport chain <ref>PMID:14672929</ref>. | [[Image:Succinate Dehydrogenase.png|left|250px]][[Succinate Dehydrogenase]] (PDB = [[2wdv]] with empty ubiquinone binding site; PDB = [[1nek]] with ubiquinone bound), also called '''succinate-coenzyme Q reductase''' (SQR) or '''Complex II''', is a tetrameric enzyme found in the cell membrane of some bacteria and the inner mitochondrial membrane of mammalian cells. It is classified as an α+β protein, as it contains <scene name='Michael_Vick_Sandbox_2/2wdv_sec_structure/1'>segregated regions</scene> of α helices and antiparallel β sheets. It is involved in two aspects of digestion; it catalyzes the oxidation of succinate to fumarate in the [[The_Citric_Acid_Cycle|citric acid cycle]] by simultaneously reducing ubiquinone to ubiquinol in the electron transport chain <ref>PMID:14672929</ref>. | ||
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[[2wp9]] - EcSDH flavoprotein + Fe-S protein (mutant) + cytochrome B-556 + membrane anchor protein subunits<br /> | [[2wp9]] - EcSDH flavoprotein + Fe-S protein (mutant) + cytochrome B-556 + membrane anchor protein subunits<br /> | ||
[[2ws3]], [[2wu2]], [[2wu5]] - EcSDH flavoprotein + Fe-S protein + cytochrome B-556 + membrane anchor protein subunits (mutant)<br /> | [[2ws3]], [[2wu2]], [[2wu5]] - EcSDH flavoprotein + Fe-S protein + cytochrome B-556 + membrane anchor protein subunits (mutant)<br /> | ||
[[3aef]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits - pig<br /> | [[3aef]], [[1zoy]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits - pig<br /> | ||
[[3vra]], [[3vr8]] - prSDH flavoprotein + Fe-S protein + cytochrome B subunits – pig roundworm<br /> | [[3vra]], [[3vr8]] - prSDH flavoprotein + Fe-S protein + cytochrome B subunits – pig roundworm<br /> | ||
[[2h88]] - cSDH flavoprotein + IP + cytochrome B subunits - chicken<br /> | [[2h88]] - cSDH flavoprotein + IP + cytochrome B subunits - chicken<br /> | ||
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[[3sfd]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits + oxalacetate + pentachlorophenol<br /> | [[3sfd]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits + oxalacetate + pentachlorophenol<br /> | ||
[[3sfe]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits + oxalacetate + thiabendazole<br /> | [[3sfe]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits + oxalacetate + thiabendazole<br /> | ||
[[1zp0]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits + thenoyltrifluoroactone + nitropropionate<br /> | |||
[[1yq3]] - cSDH flavoprotein + IP + cytochrome B subunits + ubiquinone + oxalacetate<br /> | [[1yq3]] - cSDH flavoprotein + IP + cytochrome B subunits + ubiquinone + oxalacetate<br /> | ||
[[1yq4]] - cSDH flavoprotein + IP + cytochrome B subunits + ubiquinone + nitropropionate<br /> | [[1yq4]] - cSDH flavoprotein + IP + cytochrome B subunits + ubiquinone + nitropropionate<br /> | ||