4bsx: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4bsx|  PDB=4bsx  |  SCENE=  }}
+===Crystal Structure of the N terminal domain of TRIF (TIR-domain- containing adapter-inducing interferon-beta)===
-The entry 4bsx is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/TCAM1_HUMAN TCAM1_HUMAN]] Herpetic encephalitis. Herpes simplex encephalitis 4 (HSE4) [MIM:[http://omim.org/entry/614850 614850]]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:22105173</ref>
-Authors: Ullah, M.O., Ve, T., Mangan, M., Alaidarous, M., Sweet, M.J., Mansell, A., Kobe, B.
+==Function==
+[[http://www.uniprot.org/uniprot/TCAM1_HUMAN TCAM1_HUMAN]] Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.<ref>PMID:12471095</ref> <ref>PMID:12539043</ref> <ref>PMID:14739303</ref>
-Description: Crystal Structure of the N terminal domain of TRIF (TIR-domain-containing adapter-inducing interferon-beta)
+==About this Structure==
+[[4bsx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSX OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Alaidarous, M.]]
+[[Category: Kobe, B.]]
+[[Category: Mangan, M.]]
+[[Category: Mansell, A.]]
+[[Category: Sweet, M J.]]
+[[Category: Ullah, M O.]]
+[[Category: Ve, T.]]
+[[Category: Apoptosis]]
+[[Category: Ifit protein]]
+[[Category: Innate immunity]]