4luv: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4luv|  PDB=4luv  |  SCENE=  }}
+===Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions===
+{{ABSTRACT_PUBMED_24147804}}
-The entry 4luv is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>   Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
-Authors: Feldkamp, M.D., Frank, A.O., Kennedy, J.P., Waterson, A.G., Olejnczak, E.O., Pelz, N.F., Patrone, J.D., Vangamudi, B., Camper, D.V., Rossanese, O.W., Fesik, S.W., Chazin, W.J.
+==About this Structure==
+[[4luv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LUV OCA].
-Description: Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
+==Reference==
+<ref group="xtra">PMID:024147804</ref><references group="xtra"/><references/>
+[[Category: Camper, D V.]]
+[[Category: Chazin, W J.]]
+[[Category: Feldkamp, M D.]]
+[[Category: Fesik, S W.]]
+[[Category: Frank, A O.]]
+[[Category: Kennedy, J P.]]
+[[Category: Olejnczak, E O.]]
+[[Category: Patrone, J D.]]
+[[Category: Pelz, N F.]]
+[[Category: Rossanese, O W.]]
+[[Category: Vangamudi, B.]]
+[[Category: Waterson, A G.]]
+[[Category: Dna binding protein-inhibitor complex]]
+[[Category: Ob-fold]]
+[[Category: Protein binding]]
+[[Category: Protein-protein interaction]]