2reb: Difference between revisions
New page: left|200px<br /><applet load="2reb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2reb, resolution 2.3Å" /> '''THE STRUCTURE OF THE ... |
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[[Image:2reb.gif|left|200px]]<br /><applet load="2reb" size=" | [[Image:2reb.gif|left|200px]]<br /><applet load="2reb" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2reb, resolution 2.3Å" /> | caption="2reb, resolution 2.3Å" /> | ||
'''THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER'''<br /> | '''THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the recA protein from Escherichia coli at 2.3-A | The crystal structure of the recA protein from Escherichia coli at 2.3-A resolution reveals a major domain that binds ADP and probably single- and double-stranded DNA. Two smaller subdomains at the N and C termini protrude from the protein and respectively stabilize a 6(1) helical polymer of protein subunits and interpolymer bundles. This polymer structure closely resembles that of recA/DNA filaments determined by electron microscopy. Mutations in recA protein that enhance coprotease, DNA-binding and/or strand-exchange activity can be explained if the interpolymer interactions in the crystal reflect a regulatory mechanism in vivo. | ||
==About this Structure== | ==About this Structure== | ||
2REB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] Full crystallographic information is available from [http:// | 2REB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Steitz, T | [[Category: Steitz, T A.]] | ||
[[Category: Story, R | [[Category: Story, R M.]] | ||
[[Category: homologous recombination]] | [[Category: homologous recombination]] | ||
[[Category: self-cleavage stimulation]] | [[Category: self-cleavage stimulation]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:46:45 2008'' | ||
