3q8h: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3q8h| PDB=3q8h | SCENE= }} | {{STRUCTURE_3q8h| PDB=3q8h | SCENE= }} | ||
===Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with cytidine derivative EBSI01028=== | ===Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with cytidine derivative EBSI01028=== | ||
{{ | {{ABSTRACT_PUBMED_24157367}} | ||
==Function== | ==Function== | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
[[3q8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3q8h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8H OCA]. | ||
==See Also== | ==See Also== | ||
| Line 13: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:024157367</ref><references group="xtra"/><references/> | ||
[[Category: Bacillus pseudomallei whitmore 1913]] | |||
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]] | [[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]] | ||
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | [[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | ||
[[Category: Isoprene biosynthesis]] | [[Category: Isoprene biosynthesis]] | ||
Revision as of 15:37, 11 December 2013
Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with cytidine derivative EBSI01028Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with cytidine derivative EBSI01028
Template:ABSTRACT PUBMED 24157367
FunctionFunction
[ISPF_BURPS] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]
About this StructureAbout this Structure
3q8h is a 3 chain structure with sequence from "bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ. Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6860-3. doi: 10.1016/j.bmcl.2013.09.101., Epub 2013 Oct 8. PMID:24157367 doi:http://dx.doi.org/10.1016/j.bmcl.2013.09.101