Estrogen receptor: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='Estr1.pdb' size='450' side='right' scene='Journal:JMEDCHEM:1/Cv/2' caption='Estrogen receptor complex | <StructureSection load='Estr1.pdb' size='450' side='right' scene='Journal:JMEDCHEM:1/Cv/2' caption='Estrogen Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex (PDB code [[2yat]])'> | ||
[[Image: | [[Image:2yat.png|left|200px|thumb|Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex [[2yat]]]] | ||
{{Clear}} | {{Clear}} | ||
'''Estrogen receptors''' (ER) are activated by the hormone estrogen (EST). The activated ER binds DNA and regulates the activity of many genes. There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ. ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription. | '''Estrogen receptors''' (ER) are activated by the hormone estrogen (EST). The activated ER binds DNA and regulates the activity of many genes. There are 2 forms of ER: α and β and ER dimers can be of αα, ββ and αβ. ER is composed of 5 domains: N terminal A/B domain can transactivate transcription without binding estrogen; C domain (DBD) binds to Estrogen response elements of DNA; D domain is a hinge region; E domain is ligand binding (LBD) as well as binding the coactivator and corepressor proteins and transactivates gene transcription. | ||