Molecular Playground/Bacterial Chemotaxis Complex: Difference between revisions

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Elizabeth R. Haglin, Michal Harel, Maryam Kashefy

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	One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst.		One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst.

	Bacterial chemotaxis is a method for cells to sense and adapt to chemicals in their environment. It is carried out by large arrays of membrane associated multi-protein complexes that form at the poles of the cells. The major players involved are the receptor, histidine kinase CheA, and adaptor protein CheW. ~~Upon ligand binding~~ to the receptor ~~– be it attractant or repellant – a~~ signal ~~is relayed~~ to CheA~~, which subsequently phosphorylates CheY~~		Bacterial chemotaxis is a method for cells to sense and adapt to chemicals in their environment. It is carried out by large arrays of membrane associated multi-protein complexes that form at the poles of the cells. The major players involved are the transmembrane receptor, histidine kinase CheA, and adaptor protein CheW. Repellants and attractants bind to the periplasmic domain of the receptor which then relays the signal within the cell to ultimately control CheA's kinase activity.