Sandbox Reserved 772: Difference between revisions
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[[Image:Monomer.gif |300px]]<ref name="pnas">PNAS 2002 99 (4) 1859-1864; published ahead of print February 12, 2002, doi:10.1073/pnas.022476199</ref> | [[Image:Monomer.gif |300px]]<ref name="pnas">PNAS 2002 99 (4) 1859-1864; published ahead of print February 12, 2002, doi:10.1073/pnas.022476199</ref> | ||
'''Figure 1.''' ''(A) Stereo view of the monomer. Domains: 1, blue; 2, green; 3, orange; 4, magenta. L-histidinol, NAD, and the Zn2� are shown as ball-and-sticks. ( B) Domain 1. Rossmann fold shown in blue, V-shaped pairs of helices (residues 25 –103) connected by a linker that forms the sixth strand are in cyan. (C) Domain 2. Rossmann fold (green) in similar orientation as B. Strand-helix hairpin completes the �-sheet (residues 1–24, magenta). (D) Topology diagram. Secondary structure elements are numbered consecutively. The chain meanders between domains in the order 2 –1-3–1-2–1-3– 4. (E) HisD dimer with one molecule colored as in A and the other shown in pale colors. Zn2� atoms and NAD bound to each monomer (red) define the position of the active site.'' | '''Figure 1.''' ''(A) Stereo view of the monomer. Domains: 1, blue; 2, green; 3, orange; 4, magenta. L-histidinol, NAD, and the Zn2� are shown as ball-and-sticks. ( B) Domain 1. Rossmann fold shown in blue, V-shaped pairs of helices (residues 25 –103) connected by a linker that forms the sixth strand are in cyan. (C) Domain 2. Rossmann fold (green) in similar orientation as B. Strand-helix hairpin completes the �-sheet (residues 1–24, magenta). (D) Topology diagram. Secondary structure elements are numbered consecutively. The chain meanders between domains in the order 2 –1-3–1-2–1-3– 4. (E) HisD dimer with one molecule colored as in A and the other shown in pale colors. Zn2� atoms and NAD bound to each monomer (red) define the position of the active site.<ref name="pnas">PNAS 2002 99 (4) 1859-1864; published ahead of print February 12, 2002, doi:10.1073/pnas.022476199<http://www.pnas.org.prox.lib.ncsu.edu/content/99/4/1859.full.pdf></ref> '' | ||
'''Sequence of HDH''' <ref name="structure">http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1K75&bionumber=1</ref> | '''Sequence of HDH''' <ref name="structure">http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1K75&bionumber=1</ref> | ||