Sandbox Reserved 772: Difference between revisions
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Histidinol dehydrogenase (HDH) is an enzyme that catalyzes the last step in the histidine biosynthetic pathway, which converts L-histidinol to L-histidine with a L-histidinaldehyde intermediate. This primordial pathway was found in bacteria, archaebacteria, fungi, and plants. HDH has been one of the most studied enzyme biochemically and genetically throughout time.<ref name="pnas">PNAS 2002 99 (4) 1859-1864; published ahead of print February 12, 2002, doi:10.1073/pnas.022476199</ref> | Histidinol dehydrogenase (HDH) is an enzyme that catalyzes the last step in the histidine biosynthetic pathway, which converts L-histidinol to L-histidine with a L-histidinaldehyde intermediate. This primordial pathway was found in bacteria, archaebacteria, fungi, and plants. HDH has been one of the most studied enzyme biochemically and genetically throughout time.<ref name="pnas">PNAS 2002 99 (4) 1859-1864; published ahead of print February 12, 2002, doi:10.1073/pnas.022476199</ref> | ||
HDH is encoded by the structural gene ''hisD'' in Brucellosis, commonly known as Maltafeve. Brucellosis is a bacterial disease transmitted by having contact with infected animals. HDH being encoded by ''hisD'' is essential for intramacrophagic replication because it provides a novel target for the development of anti-Brucella agent.<ref name="article5"> | HDH is encoded by the structural gene ''hisD'' in Brucellosis, commonly known as Maltafeve. Brucellosis is a bacterial disease transmitted by having contact with infected animals. HDH being encoded by ''hisD'' is essential for intramacrophagic replication because it provides a novel target for the development of anti-Brucella agent.<ref name="article5">J. Pascale, M. Abdo, R. Boigegrain, J. Montero, J. Winum, S. Kohler. "Targeting of the Brucella Suis Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen." American Society for Microbiology (2007): N. pag. Web. 27 Nov. 2013. <http://aac.asm.org/content/51/10/3752.short>.</ref> Because HDH is absent from mammals, it has become an attractive target for inhibition as part of the herbicide development.<ref name="pnas">PNAS 2002 99 (4) 1859-1864; published ahead of print February 12, 2002, doi:10.1073/pnas.022476199</ref> | ||
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