User:Alisha, Deepa, Pamiz/Sandbox 1: Difference between revisions

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H+/K+-ATPase signal pathway (acetylcholine, histamine, and gastrin) activates the pump in order to move the vesicles toward the lumen.9 These signals bind to their corresponding receptors and activate the cAMP and Ca2+ dependent pathways.9 Increased levels of intracellular Ca2+ and cAMP will promote the translocation of vesicles to the canalicular membrane, activating the H+/K+-ATPase.9 Histamine binds to Histamine H2, and sends a signal through a G protein which activates adenylate cyclase, and catalyzes the conversion of ATP to cAMP.9 Gastrin will stimulate the release of histamine by binding to CCK2.9 Acetylcholine binds to Muscarinic M3 and releases Ca2+ from the endoplasmic reticulum.9

H+/K+-ATPase signal pathway (acetylcholine, histamine, and gastrin) activates the pump in order to move the vesicles toward the lumen [13]. These signals bind to their corresponding receptors and activate the cAMP and Ca2+ dependent pathways [13]. Increased levels of intracellular Ca2+ and cAMP will promote the translocation of vesicles to the canalicular membrane, activating the H+/K+-ATPase [13]. Histamine binds to Histamine H2, and sends a signal through a G protein which activates adenylate cyclase, and catalyzes the conversion of ATP to cAMP [13].Gastrin will stimulate the release of histamine by binding to CCK2 [13]. Acetylcholine binds to Muscarinic M3 and releases Ca2+ from the endoplasmic reticulum [13].

[[Image:signaling pathway 2.gif]]

[[Image:signaling pathway 2.gif]] [14]

== Esomeprazole Mechanism ==

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-H+/K+-ATPase signal pathway (acetylcholine, histamine, and gastrin) activates the pump in order to move the vesicles toward the lumen.9 These signals bind to their corresponding receptors and activate the cAMP and  Ca2+ dependent pathways.9 Increased levels of intracellular Ca2+ and cAMP will promote the translocation of vesicles to the canalicular membrane, activating the H+/K+-ATPase.9 Histamine binds to Histamine H2, and sends a signal through a G protein which activates adenylate cyclase, and catalyzes the conversion of ATP to cAMP.9 Gastrin will stimulate the release of histamine by binding to CCK2.9 Acetylcholine binds to Muscarinic M3 and releases Ca2+ from the endoplasmic reticulum.9
+H+/K+-ATPase signal pathway (acetylcholine, histamine, and gastrin) activates the pump in order to move the vesicles toward the lumen [13]. These signals bind to their corresponding receptors and activate the cAMP and  Ca2+ dependent pathways  [13]. Increased levels of intracellular Ca2+ and cAMP will promote the translocation of vesicles to the canalicular membrane, activating the H+/K+-ATPase [13]. Histamine binds to Histamine H2, and sends a signal through a G protein which activates adenylate cyclase, and catalyzes the conversion of ATP to cAMP [13].Gastrin will stimulate the release of histamine by binding to CCK2 [13]. Acetylcholine binds to Muscarinic M3 and releases Ca2+ from the endoplasmic reticulum [13].
-                                       [[Image:signaling pathway 2.gif]]
+                                       [[Image:signaling pathway 2.gif]] [14]
 == Esomeprazole Mechanism ==