User:Alisha, Deepa, Pamiz/Sandbox 1: Difference between revisions

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== Introduction ==

[[Image:eso.jpg|300px|left|thumb|'''2D Structure & Biochemical Parameters of Esomeprazole''' Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole.

[[Image:eso.jpg|300px|left|thumb|'''2D Structure & Biochemical Parameters of Esomeprazole''' Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group [3]. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole [4,5].

]]'''Esomeprazole''' is the (S) enantiomer of Omeprazole. Esomperazole is a '''Proton Pump Inhibitor (PPI)''' that binds to '''H+/K+-ATPase''' and inhibits the secretion of gastric acid from parietal cells into the lumen of the stomach. Esomeprazole’s commercial brand name, Nexium, is used to treat Gastro-esophageal Reflux Disease (GERD), peptic and gastric ulcers, and Zollinger-Ellison syndrome [1].

Ulcers caused by the bacterium ''Helicobacter pylori'' can be treated using Esomeprazole in conjunction with proper antibiotics [1]. Gastric acid is released through the H+/K+-ATPase pump, which is the final step in acid release [2]. Esomeprazole is a specific, irreversible inhibitor of the pump [2].

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 == Introduction ==
-[[Image:eso.jpg|300px|left|thumb|'''2D Structure & Biochemical Parameters of Esomeprazole''' Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole.
+[[Image:eso.jpg|300px|left|thumb|'''2D Structure & Biochemical Parameters of Esomeprazole''' Esomeprazole has two important pyridine and benzimidazole moieties linked through a methylenesulfinyl group [3]. pKa, IC50, AUC, Cmax, and half life values of Esomeprazole [4,5].
 ]]'''Esomeprazole''' is the (S) enantiomer of Omeprazole. Esomperazole is a '''Proton Pump Inhibitor (PPI)''' that binds to '''H+/K+-ATPase''' and inhibits the secretion of gastric acid from parietal cells into the lumen of the stomach. Esomeprazole’s commercial brand name, Nexium, is used to treat Gastro-esophageal Reflux Disease (GERD), peptic and gastric ulcers, and Zollinger-Ellison syndrome [1].
 Ulcers caused by the bacterium ''Helicobacter pylori'' can be treated using Esomeprazole in conjunction with proper antibiotics [1]. Gastric acid is released through the H+/K+-ATPase pump, which is the final step in acid release [2]. Esomeprazole is a specific, irreversible inhibitor of the pump [2].