2a8a: Difference between revisions
No edit summary |
No edit summary |
||
| Line 22: | Line 22: | ||
[[Category: botulinum neurotoxin serotype f; catalytic domain; x-ray; zinc endopeptidase]] | [[Category: botulinum neurotoxin serotype f; catalytic domain; x-ray; zinc endopeptidase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:34:09 2007'' | ||
Revision as of 17:29, 30 October 2007
|
Crystal structure of Clostridium botulinum neurotoxin serotype F light chain
OverviewOverview
The seven serologically distinct Clostridium botulinum neurotoxins (BoNTs, A-G) are zinc endopeptidases which block the neurotransmitter release by, cleaving one of the three proteins of the soluble, N-ethylmaleimide-sensitive-factor attachment protein receptor complex, (SNARE complex) essential for the fusion of vesicles containing, neurotransmitters with target membranes. These metallopeptidases exhibit, unique specificity for the substrates and peptide bonds they cleave., Development of countermeasures and therapeutics for BoNTs is a priority, because of their extreme toxicity and potential misuse as biowarfare, agents. Though they share sequence homology and structural similarity, the, structural information on each one of them is required to understand the, mechanism of action of all ... [(full description)]
About this StructureAbout this Structure
2A8A is a [Single protein] structure of sequence from [Clostridium botulinum] with ZN and CD as [ligands]. Active as [Bontoxilysin], with EC number [3.4.24.69]. Structure known Active Sites: CDA, CDB and ZNB. Full crystallographic information is available from [OCA].
ReferenceReference
Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design., Agarwal R, Binz T, Swaminathan S, Biochemistry. 2005 Sep 6;44(35):11758-65. PMID:16128577
Page seeded by OCA on Tue Oct 30 16:34:09 2007