Sandbox Reserved 771: Difference between revisions
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==Alternative Splicing Variants== | ==Alternative Splicing Variants== | ||
While the expression of glutathione synthetase (GSS) has been studied and fairly well characterized, the sequence and alternative splicing of the gss gene has been studied very little. Using real-time polymerase chain reaction (qPCR) to quantify mRNA levels of the gss transcript within human cells has revealed one common alternative splicing variant present within colon, kidney, lung, liver, placenta, blood, and uterus cells. It has not, however, been detected within heart, skeletal muscle, and spleen tissue cells. This ASV is produced from a 333 bp in-frame deletion, including the complete removal of exons 4 and 5. | |||
==Chronic Lung Infections Caused by Alterations to Glutathione Synthesis== | ==Chronic Lung Infections Caused by Alterations to Glutathione Synthesis== | ||