Sandbox Reserved 772: Difference between revisions
Jah Ia Yang (talk | contribs) No edit summary |
Jah Ia Yang (talk | contribs) No edit summary |
||
| Line 11: | Line 11: | ||
==Histidinol Dehydrogenase== | ==Histidinol Dehydrogenase== | ||
Histidinol dehydrogenase (HDH) is an enzyme that catalyzes the last step in the histidine biosynthetic pathway, which converts L-histidinol to L-histidine with a L-histidinaldehyde intermediate. This primordial pathway was found in bacteria, archaebacteria, fungi, and plants. HDH has been one of the most studied enzyme biochemically and genetically throughout time | Histidinol dehydrogenase (HDH) is an enzyme that catalyzes the last step in the histidine biosynthetic pathway, which converts L-histidinol to L-histidine with a L-histidinaldehyde intermediate. This primordial pathway was found in bacteria, archaebacteria, fungi, and plants. HDH has been one of the most studied enzyme biochemically and genetically throughout time.<ref name="pnas">http://www.pnas.org.prox.lib.ncsu.edu/content/99/4/1859.full.pdf</ref> | ||
HDH is encoded by the structural gene hisD in Brucellosis, commonly known as Maltafeve. This is essential for intramacrophagic replication because it provides a novel target for the development of anti-Brucella agent.<ref name="article5">http://aac.asm.org/content/51/10/3752.full.pdf+html</ref> HDH is absent from mammals; therefore, it has become an attractive target for inhibition as part of the herbicide development.<ref name="pnas">http://www.pnas.org.prox.lib.ncsu.edu/content/99/4/1859.full.pdf</ref> | |||
__TOC__ | __TOC__ | ||