2qrn: Difference between revisions
New page: left|200px<br /><applet load="2qrn" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qrn, resolution 3.40Å" /> '''Human Deoxycytidine ... |
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==Overview== | ==Overview== | ||
Human deoxycytidine kinase (dCK) is involved in the | Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ealick, S | [[Category: Ealick, S E.]] | ||
[[Category: Soriano, E | [[Category: Soriano, E V.]] | ||
[[Category: DCM]] | [[Category: DCM]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: uridine diphosphate]] | [[Category: uridine diphosphate]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:41:45 2008'' | ||
