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{{STRUCTURE_4hsl| PDB=4hsl | SCENE= }} | |||
===2.00 angstrom x-ray crystal structure of substrate-bound E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/3HAO_RALME 3HAO_RALME]] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.<ref>PMID:15909977</ref> | |||
==About this Structure== | |||
[[4hsl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSL OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]] | |||
[[Category: Chen, L.]] | |||
[[Category: Liu, A.]] | |||
[[Category: Liu, F.]] | |||
[[Category: Bi-cupin iron-binding]] | |||
[[Category: Dioxygenase]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 13:29, 27 November 2013
2.00 angstrom x-ray crystal structure of substrate-bound E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans2.00 angstrom x-ray crystal structure of substrate-bound E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans
FunctionFunction
[3HAO_RALME] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.[1]
About this StructureAbout this Structure
4hsl is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Colabroy KL, Zhai H, Li T, Ge Y, Zhang Y, Liu A, Ealick SE, McLafferty FW, Begley TP. The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry. 2005 May 31;44(21):7623-31. PMID:15909977 doi:http://dx.doi.org/10.1021/bi0473455