4lf3: Difference between revisions
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{{STRUCTURE_4lf3| PDB=4lf3 | SCENE= }} | {{STRUCTURE_4lf3| PDB=4lf3 | SCENE= }} | ||
===Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor=== | ===Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor=== | ||
{{ABSTRACT_PUBMED_24189067}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4lf3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LF3 OCA]. | [[4lf3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LF3 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024189067</ref><references group="xtra"/><references/> | |||
[[Category: Human]] | |||
[[Category: Lk3 transgenic mice]] | |||
[[Category: Mukund, S.]] | [[Category: Mukund, S.]] | ||
[[Category: Murray, J M.]] | [[Category: Murray, J M.]] | ||
Revision as of 11:41, 27 November 2013
Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon ReceptorInhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor
Template:ABSTRACT PUBMED 24189067
FunctionFunction
[GLR_HUMAN] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
About this StructureAbout this Structure
4lf3 is a 6 chain structure with sequence from Human and Lk3 transgenic mice. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Mukund S, Shang Y, Clarke HJ, Madjidi A, Corn JE, Kates L, Kolumam G, Chiang V, Luis E, Murray J, Zhang Y, Hotzel I, Koth CM, Allan BB. Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor. J Biol Chem. 2013 Nov 4. PMID:24189067 doi:http://dx.doi.org/10.1074/jbc.M113.496984