Serine hydroxymethyltransferase: Difference between revisions
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<Structure load='1kkj' size='450' frame='true' align='right' caption='Structure of [[Serine hydroxymethyltransferase]] isolated from Bacillus stearothermophilus' scene='Insert optional scene name here' /> | <Structure load='1kkj' size='450' frame='true' align='right' caption='Structure of [[Serine hydroxymethyltransferase]] isolated from Bacillus stearothermophilus' scene='Insert optional scene name here' /> | ||
===Function=== | ===Function=== | ||
[[Serine hydroxymethyltransferase]] (SHMT) is part of the pyridoxal phosphate (PLP)-dependent enzymes. The enzyme is broadly classified as a transferase enzyme. Transferase enzymes primarily work by catalyzing the transfer of a specific functional group from one molecule to another. For example, a methyl group may need to be transferred from one molecule to another in ''vivo''. The transferase enzymes will catalyze the transfer of this methyl group.Specifically, the enzyme belongs to the alpha-class. This enzyme is utilized mainly for two functions. First, the enzyme catalyzes the reversible conversion of serine to glycine. Second, the enzyme catalyzes the reversible conversion of tetrahydrofolate to 5,10-methylene tetrahydrofolate. | [[Serine hydroxymethyltransferase]] (SHMT) is part of the pyridoxal phosphate (PLP)-dependent enzymes. The enzyme is broadly classified as a transferase enzyme. Transferase enzymes primarily work by catalyzing the transfer of a specific functional group from one molecule to another. For example, a methyl group may need to be transferred from one molecule to another in ''vivo''. The transferase enzymes will catalyze the transfer of this methyl group. | ||
Specifically, the enzyme belongs to the alpha-class. This enzyme is utilized mainly for two functions. First, the enzyme catalyzes the reversible conversion of L-serine to L-glycine. Second, the enzyme catalyzes the reversible conversion of tetrahydrofolate to 5,10-methylene tetrahydrofolate. | |||
===Diversity/Importance=== | ===Diversity/Importance=== | ||