3o2f: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3o2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2F OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023995768</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023995768</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Canfa]] | ||
[[Category: Gewirth, D T.]] | [[Category: Gewirth, D T.]] | ||
[[Category: Seidler, P M.]] | [[Category: Seidler, P M.]] | ||
[[Category: Chaperone-inhibitor complex]] | [[Category: Chaperone-inhibitor complex]] | ||
[[Category: Hsp90 heat-shock protein]] | [[Category: Hsp90 heat-shock protein]] | ||
Revision as of 15:22, 20 November 2013
Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54
Template:ABSTRACT PUBMED 23995768
FunctionFunction
[ENPL_CANFA] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
About this StructureAbout this Structure
3o2f is a 2 chain structure with sequence from Canfa. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Sep 1. doi: 10.1038/nchembio.1335. PMID:23995768 doi:10.1038/nchembio.1335