2fzh: Difference between revisions
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{{STRUCTURE_2fzh| PDB=2fzh | SCENE= }} | {{STRUCTURE_2fzh| PDB=2fzh | SCENE= }} | ||
===New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives=== | ===New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives=== | ||
{{ABSTRACT_PUBMED_17019704}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | ==About this Structure== | ||
[[2fzh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2fzh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneca Pneca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZH OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017019704</ref><references group="xtra"/> | <ref group="xtra">PMID:017019704</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: | [[Category: Pneca]] | ||
[[Category: Chisum, K.]] | [[Category: Chisum, K.]] | ||
[[Category: Cody, V.]] | [[Category: Cody, V.]] | ||
Revision as of 15:19, 20 November 2013
New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim DerivativesNew Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives
Template:ABSTRACT PUBMED 17019704
FunctionFunction
[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this StructureAbout this Structure
2fzh is a 1 chain structure with sequence from Pneca. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Cody V, Pace J, Chisum K, Rosowsky A. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Proteins. 2006 Dec 1;65(4):959-69. PMID:17019704 doi:10.1002/prot.21131