3jwm: Difference between revisions
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{{STRUCTURE_3jwm| PDB=3jwm | SCENE= }} | {{STRUCTURE_3jwm| PDB=3jwm | SCENE= }} | ||
===Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and (S)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A)=== | ===Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and (S)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A)=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | |||
==About this Structure== | ==About this Structure== | ||
[[3jwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3jwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWM OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020882962</ref><references group="xtra"/> | <ref group="xtra">PMID:020882962</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Anderson, A C.]] | [[Category: Anderson, A C.]] | ||
[[Category: Beierlein, J M.]] | [[Category: Beierlein, J M.]] | ||
[[Category: Karri, N G.]] | [[Category: Karri, N G.]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||