4jxt: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4jxt|  PDB=4jxt  |  SCENE=  }}
+===CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD===
-The entry 4jxt is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RPR1A_HUMAN RPR1A_HUMAN]] Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.<ref>PMID:12470661</ref> <ref>PMID:22231121</ref>  [[http://www.uniprot.org/uniprot/RPB1_HUMAN RPB1_HUMAN]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.<ref>PMID:9852112</ref> <ref>PMID:18032511</ref>
-Authors: Ni, Z., Xu, C., Tempel, W., El Bakkouri, M., Loppnau, P., Guo, X., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Greenblatt, J.F., Structural Genomics Consortium (SGC)
+==About this Structure==
+[[4jxt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JXT OCA].
-Description: CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Arrowsmith, C H.]]
+[[Category: Bakkouri, M El.]]
+[[Category: Bountra, C.]]
+[[Category: Edwards, A M.]]
+[[Category: Greenblatt, J F.]]
+[[Category: Guo, X.]]
+[[Category: Loppnau, P.]]
+[[Category: Min, J.]]
+[[Category: Ni, Z.]]
+[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Tempel, W.]]
+[[Category: Weigelt, J.]]
+[[Category: Xu, C.]]
+[[Category: Protein binding]]
+[[Category: Sgc]]
+[[Category: Structural genomic]]
+[[Category: Structural genomics consortium]]