Sandbox 1k4r: Difference between revisions
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Dengue virus is a mosquito borne illness and is a major threat in most of the tropical and sub-tropical countries around the world. There are four related subtypes of the Dengue virus. Dengue is not transmitted directly from person-to-person and symptoms range from a mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. There is no vaccine or any specific medicine to treat dengue. People who have dengue fever should rest, drink plenty of fluids and reduce the fever using paracetamol or see a doctor. | Dengue virus is a mosquito borne illness and is a major threat in most of the tropical and sub-tropical countries around the world. There are four related subtypes of the Dengue virus. Dengue is not transmitted directly from person-to-person and symptoms range from a mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. There is no vaccine or any specific medicine to treat dengue. People who have dengue fever should rest, drink plenty of fluids and reduce the fever using paracetamol or see a doctor. | ||
==About this Structure== | ==About this Structure== | ||
'''Dengue Virus Genome''' carries only one single strand of RNA as its genome. This genome only encodes for ten proteins (three structural and seven "production" proteins. The production proteins are useful in aiding the virus penetrating the host cell and help produce new virus structures. The outer membrane of the protein is constructed of 180 copies of the envelope protein, which this membrane helps the virus attach to the host cell membrane. | |||
[[Image:1ok8 copy.jpg]] | |||
Dengue Virus inside Cell<StructureSection load='1ok8' size='500' side='right' caption='Dengue virus inside cell (PDB entry [[1ok8]])' scene=''>When the virus is in its infectious form the surface is smooth, but as it is exposed to the acidic environment of the cell causes the proteins to snap into a trimeric spike so as to penetrate and then fuze with the lysozome membrane. | Dengue Virus inside Cell<StructureSection load='1ok8' size='500' side='right' caption='Dengue virus inside cell (PDB entry [[1ok8]])' scene=''>When the virus is in its infectious form the surface is smooth, but as it is exposed to the acidic environment of the cell causes the proteins to snap into a trimeric spike so as to penetrate and then fuze with the lysozome membrane. | ||
The trimer model of the Dengue virus is extracted in many different ways. The one observed experiment was separated by detergent extraction. The model shows a chloride ion liganded by three amide nitrogens from Lys-110. The chloride is believed to dissolve away the liposome on the trimer tip. The tip of the trimer, or <scene name='56/565763/Trimer/3'>fusion loop</scene>, displays three hydrophobic residues, Trp-101, Lys-107, and Phe-108. | The trimer model of the Dengue virus is extracted in many different ways. The one observed experiment was separated by detergent extraction. The model shows a chloride ion liganded by three amide nitrogens from Lys-110. The chloride is believed to dissolve away the liposome on the trimer tip. The tip of the trimer, or <scene name='56/565763/Trimer/3'>fusion loop</scene>, displays three hydrophobic residues, Trp-101, Lys-107, and Phe-108. | ||
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[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
== Headline text == | |||