Sandbox vdr: Difference between revisions

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Revision as of 06:47, 12 November 2013 view source Isita Amin (talk \| contribs) 62 edits No edit summary ← Older edit		Revision as of 16:54, 12 November 2013 view source Sunjeet Virdi (talk \| contribs) 59 edits No edit summary Newer edit →
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	==Mutation==		==Mutation==
	Serine/ threonine kinase plays a crucial role in signal transduction pathways drawn out by variety of growth factors, hormones, and neurotransmitters. When <scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>serine</scene> is mutated it is replaced by with <scene name='56/562378/~~Vit_d_receptor_3m7r_mutation1~~/1'>glycine</scene> which results in an inhibition of transcriptional activation. When transcription is inhibited it results in p53 accumulation, which activates and promotes p53 translocation into mitochondria leading to apoptosis. Transcription inhibition is useful in cancer patients.		Serine/ threonine kinase plays a crucial role in signal transduction pathways drawn out by variety of growth factors, hormones, and neurotransmitters. When <scene name='56/562378/Vit_d_receptor_3m7r_serine/5'>serine</scene> is mutated it is replaced by with <scene name='56/562378/Vit_d_receptor_3m7r_serine/8'>glycine</scene> which results in an inhibition of transcriptional activation. When transcription is inhibited it results in p53 accumulation, which activates and promotes p53 translocation into mitochondria leading to apoptosis. Transcription inhibition is useful in cancer patients.