4l5j: Difference between revisions
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{{STRUCTURE_4l5j| PDB=4l5j | SCENE= }} | |||
===Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition=== | |||
{{ABSTRACT_PUBMED_24047255}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LSRR_ECOLI LSRR_ECOLI]] Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.<ref>PMID:15601708</ref> <ref>PMID:15743955</ref> <ref>PMID:17557827</ref> | |||
==About this Structure== | |||
[[4l5j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5J OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024047255</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli k-12]] | |||
[[Category: Eo, Y.]] | |||
[[Category: Ha, J H.]] | |||
[[Category: Ryu, K S.]] | |||
[[Category: Dna binding]] | |||
[[Category: Dna transcriptional regulator]] | |||
[[Category: Helix-turn-helix domain]] | |||
[[Category: Phospho-ai-2 binding]] | |||
[[Category: Sorc/deor family]] | |||
[[Category: Transcription regulator]] |