Ku protein: Difference between revisions
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Unlike other DNA binding proteins, the Ku protein is asymmetrical from the differences between the Ku70 and Ku80 subunits. | Unlike other DNA binding proteins, the Ku protein is asymmetrical from the differences between the Ku70 and Ku80 subunits. | ||
This asymmetry leads to different favorable locations for DNA based on major and minor grooves.<ref name="Walker"/> | This asymmetry leads to different favorable locations for DNA based on major and minor grooves.<ref name="Walker"/> | ||
The Ku70 subunit is <scene name='56/567269/Ku70_subunit/ | The Ku70 subunit is <scene name='56/567269/Ku70_subunit/5'>angled closer</scene> to DNA at the double strand break, providing protection and interaction with its domains.<ref name="source2"> PMID: 19715578</ref> | ||
In contrast, the Ku80 subunit <scene name='56/567269/Ku80_subunit/4'>associates with</scene> DNA away from the free end.<ref name="Walker"/> Once a homodimer, the protein has diverged into two domains that are now 15% similar in residues. <ref name="source3"> PMID: 9663392</ref> | In contrast, the Ku80 subunit <scene name='56/567269/Ku80_subunit/4'>associates with</scene> DNA away from the free end.<ref name="Walker"/> Once a homodimer, the protein has diverged into two domains that are now 15% similar in residues. <ref name="source3"> PMID: 9663392</ref> | ||