Single stranded binding protein: Difference between revisions

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 SSB can form complexes with many other proteins. This trait can keep enzymes needed for damage repair, transcription, etc. near the ssDNA and it is thought that SSB can even help to stimulate these enzymes to carry out their jobs. When DNA binds SSB, most of the molecule loses flexibility. But the COOH terminal domain remain flexible, even after DNA binding. It is believed that the COOH terminus has something to do with protein binding <ref>PMID: 2087220</ref>.
-It is believed that Gly15 may play an important role in binding the RecA protein. Mutations in Gly15 have
+SSB has also been thought to bind with exonuclease I, DNA polymerase II,
-extreme effects on recombinational repair.  SSB has also been thought to bind with exonuclease I, DNA polymerase II,
 and a protein n, which is used to help synthesize RNA primers for the lagging strand. SSB can also help regulate transcription by competing with other proteins for binding spaces on DNA. SSB has a higher affinity for DNA than most other proteins, and those proteins are not able to remove SSB from DNA and bind themselves. This type of mechanism can not only regulate transcription, but it can provide protection for the DNA <ref>PMID: 2087220</ref>.
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