4buf: Difference between revisions
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{{STRUCTURE_4buf| PDB=4buf | SCENE= }} | |||
===Crystal structure of human tankyrase 2 in complex with 2-(4- acetylphenyl)-3,4-dihydroquinazolin-4-one=== | |||
{{ABSTRACT_PUBMED_24130191}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> | |||
==About this Structure== | |||
[[4buf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUF OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024130191</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Haikarainen, T.]] | |||
[[Category: Lehtio, L.]] | |||
[[Category: Narwal, M.]] | |||
[[Category: Adp- ribosylation]] | |||
[[Category: Diphtheria toxin like fold]] | |||
[[Category: Protein-ligand complex]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||