4msw: Difference between revisions

Revision as of 12:37, 30 October 2013

Y78 ester mutant of KcsA in high K+Y78 ester mutant of KcsA in high K+

FunctionFunction

[KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).^[1]

About this StructureAbout this Structure

4msw is a 3 chain structure with sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Matulef K, Komarov AG, Costantino CA, Valiyaveetil FI. Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels. Proc Natl Acad Sci U S A. 2013 Oct 15. PMID:24128761 doi:http://dx.doi.org/10.1073/pnas.1314356110

↑ Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

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OCA

[2] Matulef K, Komarov AG, Costantino CA, Valiyaveetil FI. Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels. Proc Natl Acad Sci U S A. 2013 Oct 15. PMID:24128761 doi:http://dx.doi.org/10.1073/pnas.1314356110

[1] Schrempf H, Schmidt O, Kummerlen R, Hinnah S, Muller D, Betzler M, Steinkamp T, Wagner R. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J. 1995 Nov 1;14(21):5170-8. PMID:7489706

[1]

[xtra 1]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4msw|  PDB=4msw  |  SCENE=  }}
+===Y78 ester mutant of KcsA in high K+===
+{{ABSTRACT_PUBMED_24128761}}
-The entry 4msw is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
-Authors: Matulef, K., Valiyaveetil, F.I.
+==About this Structure==
+[[4msw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSW OCA].
-Description: Y78 ester mutant of KcsA in high K+
+==Reference==
+<ref group="xtra">PMID:024128761</ref><references group="xtra"/><references/>
+[[Category: Mus musculus]]
+[[Category: Streptomyces lividans]]
+[[Category: Matulef, K.]]
+[[Category: Valiyaveetil, F I.]]
+[[Category: Channel]]
+[[Category: Ester]]
+[[Category: Membrane protein]]
+[[Category: Transport protein]]
+[[Category: Unnatural amino acid]]

4msw: Difference between revisions

Revision as of 12:37, 30 October 2013

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Y78 ester mutant of KcsA in high K+Y78 ester mutant of KcsA in high K+

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About this StructureAbout this Structure

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4msw: Difference between revisions

Revision as of 12:37, 30 October 2013

Y78 ester mutant of KcsA in high K+Y78 ester mutant of KcsA in high K+

FunctionFunction

About this StructureAbout this Structure

ReferenceReference

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