4n0b: Difference between revisions
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{{STRUCTURE_4n0b| PDB=4n0b | SCENE= }} | |||
===Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of GabT=== | |||
{{ABSTRACT_PUBMED_24127574}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU]] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref> | |||
==About this Structure== | |||
[[4n0b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0B OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024127574</ref><references group="xtra"/><references/> | |||
[[Category: Bacillus subtilis]] | |||
[[Category: Bach, A.]] | |||
[[Category: Belitsky, B R.]] | |||
[[Category: Edayathumangalam, R.]] | |||
[[Category: Garcia, R.]] | |||
[[Category: Hoang, Q Q.]] | |||
[[Category: Kreinbring, C A.]] | |||
[[Category: Liao, J.]] | |||
[[Category: Liu, D.]] | |||
[[Category: Petsko, G A.]] | |||
[[Category: Ringe, D.]] | |||
[[Category: Stone, T.]] | |||
[[Category: Terwilliger, T.]] | |||
[[Category: Wang, W.]] | |||
[[Category: Wang, Y.]] | |||
[[Category: Wu, R.]] | |||
[[Category: Activator]] | |||
[[Category: Autorepressor]] | |||
[[Category: Transcription activator]] | |||
[[Category: Transcription factor]] | |||
[[Category: Type-i aminotransferase-like fold]] | |||
[[Category: Winged helix domain]] | |||
Revision as of 12:33, 30 October 2013
Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of GabTCrystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of GabT
Template:ABSTRACT PUBMED 24127574
FunctionFunction
[GABR_BACSU] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.[1] [2]
About this StructureAbout this Structure
4n0b is a 4 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Edayathumangalam R, Wu R, Garcia R, Wang Y, Wang W, Kreinbring CA, Bach A, Liao J, Stone TA, Terwilliger TC, Hoang QQ, Belitsky BR, Petsko GA, Ringe D, Liu D. Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT. Proc Natl Acad Sci U S A. 2013 Oct 14. PMID:24127574 doi:http://dx.doi.org/10.1073/pnas.1315887110
- ↑ Belitsky BR, Sonenshein AL. GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis. Mol Microbiol. 2002 Jul;45(2):569-83. PMID:12123465
- ↑ Belitsky BR. Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator. J Mol Biol. 2004 Jul 16;340(4):655-64. PMID:15223311 doi:http://dx.doi.org/10.1016/j.jmb.2004.05.020