Tubulin

File:1z5w.png

Crystal Structure of Tubulin 1z5w

Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, i.e. the crystal structure of Tubulin (1z5w).

3D Structures of Tubulin3D Structures of Tubulin

Updated on 23-October-2013

α-tubulinα-tubulin

2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii

α-tubulin + β-tubulinα-tubulin + β-tubulin

3hkb, 3hkc, 3hkd, 3hke, 3n2g, 3n2k, 3ryc, 3ryf, 3ryh, 3ryi – sTUBA+sTUBB+stathmin-like protein B3 – sheep
4f61 - sTUBA+sTUBB+stathmin-like protein R4
3ut5 - sTUBA+sTUBB+stathmin-like protein B3 + vinca peptide
4drx - sTUBA+sTUBB + ankyrin repeat protein
4f6r - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein
2wbe – bTUBA1D+bTUBB2B+kinesin+AMPPNP – bovine
3dco - bTUBA+bTUBB+kinesin-like NOD
1tvk - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography
3iz0 - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy
3edl - bTUBA1D+bTUBB2B+kinesin motor domain
2xrp - bTUBA1D+bTUBB2B+doublecortin
3du7, 3e22, 1z2b, 1sa0, 1sa1 – bTUBA1C+bTUBB2B+stathmin-like protein B3
1ffx - bTUBA+bTUBB+stathmin-like protein B3
1jff - bTUBA+bTUBB
4hna - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein
4ihj - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase + ADP
4iij, 4i55 - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase
3j1t, 3j1u - bTUBA+bTUBB+ dyenin
3j2u - bTUBA+bTUBB+kinesin-like KLP10A head domain
4i50, 4i4t - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase + anti-cancer agent
2p4n - hTUBA+hTUBB+kinesin heavy chain
2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig
2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
4abo - pTUBA+pTUBB+ microtubule integrity protein MAL3
1tub - pTUBA+pTUBB – electron diffraction
4aqv, 4aqw - bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM
4atu - bTUBA1D+bTUBB2B+doublecortin – Cryo EM
4atx - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM
2btq – PdTUBA+PdTUBB
4ffb - TUBA+TUBB (mutant) + protein STU2 - yeast

γ-tubulinγ-tubulin

3cb2 – hTUBG1+GDP
1z5v - hTUBG1+GTPgS
1z5w - hTUBG1+GTP
3rip – hTUBG4

FtsZFtsZ

2rhh, 2rhj – BsFtsZ+SO4 – Bacillus subtilis
2rhl - BsFtsZ+GDP
2rho - BsFtsZ+GDP+GTP-gamma-S
2vxy, 2vam – BsFtsZ
2ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa
2ve9 - PaFtsZ gamma domain+DNA
2vaw – PaFtsZ+GDP
1ofu - PaFtsZ+SULA
2r75 - AaFtsZ+8-morpholino-GTP – Aquifex aeolicus
2r6r - AaFtsZ
2q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis
2q1y, 1rlu - MtFtsZ+GTP-gamma-S
1rq7 - MtFtsZ+GDP
2vap – MjFtsZ+GDP – Methancaldococcus jannaschii
1w58 - MjFtsZ+GMPCPP
1w59, 1fsz – MjFtsZ
1w5a - MjFtsZ+MgGTP
1w5b - MjFtsZ+GTP
1w5e, 1w5f – MjFtsZ (mutant)