2pbh: Difference between revisions

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-[[Image:2pbh.gif|left|200px]]<br />
+[[Image:2pbh.gif|left|200px]]<br /><applet load="2pbh" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2pbh" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2pbh, resolution 3.3&Aring;" />
 '''CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION'''<br />
 ==Overview==
-A wild-type human procathepsin B was expressed, crystallized in two, crystal forms and its crystal structure determined at 3.2 and 3.3, Angstroms resolution. The structure reveals that the propeptide folds on, the cathepsin B surface, shielding the enzyme active site from exposure to, solvent. The structure of the enzymatically active domains is virtually, identical to that of the native enzyme [Musil et al. (1991) EMBO J. 10, 2321-2330]: the main difference is that the occluding loop residues are, lifted above the body of the mature enzyme, supporting the propeptide, structure.
+A wild-type human procathepsin B was expressed, crystallized in two crystal forms and its crystal structure determined at 3.2 and 3.3 Angstroms resolution. The structure reveals that the propeptide folds on the cathepsin B surface, shielding the enzyme active site from exposure to solvent. The structure of the enzymatically active domains is virtually identical to that of the native enzyme [Musil et al. (1991) EMBO J. 10, 2321-2330]: the main difference is that the occluding loop residues are lifted above the body of the mature enzyme, supporting the propeptide structure.
 ==About this Structure==
-PBH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PBH OCA].
+PBH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBH OCA].
 ==Reference==
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 [[Category: thiol protease]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:22:12 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:27:57 2008''