4f14: Difference between revisions
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{{STRUCTURE_4f14| PDB=4f14 | SCENE= }} | {{STRUCTURE_4f14| PDB=4f14 | SCENE= }} | ||
===Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2=== | ===Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2=== | ||
{{ABSTRACT_PUBMED_23985323}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NEBL_HUMAN NEBL_HUMAN]] Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.<ref>PMID:15004028</ref> [[http://www.uniprot.org/uniprot/XIRP2_HUMAN XIRP2_HUMAN]] Protects actin filaments from depolymerization. | |||
==About this Structure== | ==About this Structure== | ||
[[4f14]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F14 OCA]. | [[4f14]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F14 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023985323</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Sauer, F.]] | [[Category: Sauer, F.]] | ||
Revision as of 08:27, 23 October 2013
Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2Structure of the SH3 domain of human nebulette in complex with a peptide of XIRP2
Template:ABSTRACT PUBMED 23985323
FunctionFunction
[NEBL_HUMAN] Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.[1] [XIRP2_HUMAN] Protects actin filaments from depolymerization.
About this StructureAbout this Structure
4f14 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Eulitz S, Sauer F, Pelissier MC, Boisguerin P, Molt S, Schuld J, Orfanos Z, Kley RA, Volkmer R, Wilmanns M, Kirfel G, van der Ven PF, Furst DO. Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling. Mol Biol Cell. 2013 Oct;24(20):3215-26. doi: 10.1091/mbc.E13-04-0202. Epub 2013, Aug 28. PMID:23985323 doi:http://dx.doi.org/10.1091/mbc.E13-04-0202
- ↑ Li B, Zhuang L, Trueb B. Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. J Biol Chem. 2004 May 7;279(19):20401-10. Epub 2004 Mar 5. PMID:15004028 doi:10.1074/jbc.M310304200