Ribonucleotide reductase: Difference between revisions
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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Ribonucleotide reductase dimer complex with DTP and Mg+2 ion, [[1xjf]] }} | {{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Ribonucleotide reductase dimer complex with DTP and Mg+2 ion, [[1xjf]] }} | ||
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. | '''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. Class II RNR reduces ribonucleotide triphosphates using coenzyme B12. Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center. For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]]. | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
==Class I RNR== | |||
===RNR large subunit=== | ===RNR large subunit=== | ||
[[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | [[1zyz]], [[1zzd]], [[2cvs]], [[2cvt]], [[2cvu]], [[2cvv]], [[2cvw]], [[2cvx]], [[2cvy]] - yRNR R1 – yeast<BR /> | ||
[[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli'' | [[5r1r]], [[6r1r]], [[7r1r]], [[1r1r]], [[1rlr]], [[1mrr]] - EcRNR R1 – ''Escherichia coli'' | ||
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[[2eud]] - yRNR R1 + ligand<BR /> | [[2eud]] - yRNR R1 + ligand<BR /> | ||
[[3rsr]] – yRNR + inhibitor<br /> | [[3rsr]] – yRNR + inhibitor<br /> | ||
[[2r1r]] - EcRNR R1 + TTP<BR /> | [[2r1r]] - EcRNR R1 + TTP<BR /> | ||
[[3r1r]] - EcRNR R1 + AMPPNP<BR /> | [[3r1r]] - EcRNR R1 + AMPPNP<BR /> | ||
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[[4dr0]] - RNR + Mn – Bacillus subtilis<br /> | [[4dr0]] - RNR + Mn – Bacillus subtilis<br /> | ||
[[1uzr]] – RNR R2 – ''Mycobacterium tuberculosis''<BR /> | [[1uzr]] – RNR R2 – ''Mycobacterium tuberculosis''<BR /> | ||
[[3olj]] – hRNR M2<br /> | [[3olj]] – hRNR M2<br /> | ||
[[1jk0]] – yRNR Y2+Y4<br /> | |||
[[3vpm]], [[3vpn]], [[3vpo]] – hRNR M2 (mutant)<br /> | [[3vpm]], [[3vpn]], [[3vpo]] – hRNR M2 (mutant)<br /> | ||
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[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | [[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | ||
[[2bq1]] - StRNR R1+ R2 | [[2bq1]] - StRNR R1+ R2 | ||
==Class II RNR== | |||
[[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR /> | [[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR /> | ||
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[[1xjm]] - TmRNR + TTP<BR /> | [[1xjm]] - TmRNR + TTP<BR /> | ||
[[1xje]] - TmRNR + TTP-GDP<BR /> | [[1xje]] - TmRNR + TTP-GDP<BR /> | ||
[[1xjn]] - TmRNR + ATP-CDP | [[1xjn]] - TmRNR + ATP-CDP<br /> | ||
[[1pem]] - StRNR R1 - ''Salmonella typhimurium''<BR /> | |||
[[1peo]], [[1peq]], [[2peu]] - StRNR R1 + effector<BR /> | |||
[[1l1l]] – RNR (mutant) – ''Lactobacillus leichmannii''<br /> | |||
==Class III RNR== | |||
[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br /> | |||
[[1h7b]] – T4RNR (mutant) <br /> | |||