4bu0: Difference between revisions
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{{STRUCTURE_4bu0| PDB=4bu0 | SCENE= }} | |||
===Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide=== | |||
{{ABSTRACT_PUBMED_24074952}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RAD4_SCHPO RAD4_SCHPO]] Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. [[http://www.uniprot.org/uniprot/RHP9_SCHPO RHP9_SCHPO]] Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage.<ref>PMID:9153313</ref> <ref>PMID:9407031</ref> <ref>PMID:15550243</ref> | |||
==About this Structure== | |||
[[4bu0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BU0 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024074952</ref><references group="xtra"/><references/> | |||
[[Category: Schizosaccharomyces pombe]] | |||
[[Category: Carr, A M.]] | |||
[[Category: Du, L L.]] | |||
[[Category: Garcia, V.]] | |||
[[Category: Oliver, A W.]] | |||
[[Category: Pearl, L H.]] | |||
[[Category: Qu, M.]] | |||
[[Category: Rappas, M.]] | |||
[[Category: Wardlaw, C P.]] | |||
[[Category: Dna damage checkpoint]] | |||
[[Category: Replication]] | |||
[[Category: Topbp1]] |