4lhx: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4lhx|  PDB=4lhx  |  SCENE=  }}
+===Crystal structure of nucleotide-free Rab8:Rabin8===
+{{ABSTRACT_PUBMED_24072714}}
-The entry 4lhx is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RAB8A_HUMAN RAB8A_HUMAN]] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.<ref>PMID:20890297</ref> <ref>PMID:21282656</ref>  [[http://www.uniprot.org/uniprot/RAB3I_HUMAN RAB3I_HUMAN]] Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.<ref>PMID:12221131</ref> <ref>PMID:20937701</ref> <ref>PMID:20890297</ref>
-Authors: Guo, Z., Hou, X.M., Goody, R.S., Itzen, A.
+==About this Structure==
+[[4lhx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHX OCA].
-Description: Crystal structure of nucleotide-free Rab8:Rabin8
+==Reference==
+<ref group="xtra">PMID:024072714</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Goody, R S.]]
+[[Category: Guo, Z.]]
+[[Category: Hou, X M.]]
+[[Category: Itzen, A.]]
+[[Category: Guanine nucleotide exchange factor]]
+[[Category: Protein transport]]
+[[Category: Small gtpase]]