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{{STRUCTURE_4dfe| PDB=4dfe | SCENE= }} | {{STRUCTURE_4dfe| PDB=4dfe | SCENE= }} | ||
===Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Burkholderia xenovorans=== | ===Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Burkholderia xenovorans=== | ||
{{ABSTRACT_PUBMED_23382856}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q13VL5_BURXL Q13VL5_BURXL]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).[HAMAP-Rule:MF_01815] | |||
==About this Structure== | ==About this Structure== | ||
[[4dfe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4dfe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_xenovorans_lb400 Burkholderia xenovorans lb400]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DFE OCA]. | ||
==See Also== | ==See Also== | ||
*[[Acyl carrier protein synthase|Acyl carrier protein synthase]] | *[[Acyl carrier protein synthase|Acyl carrier protein synthase]] | ||
[[Category: Burkholderia xenovorans]] | ==Reference== | ||
<ref group="xtra">PMID:023382856</ref><references group="xtra"/><references/> | |||
[[Category: Burkholderia xenovorans lb400]] | |||
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | [[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | ||
[[Category: Seattle structural genomics center for infectious disease]] | [[Category: Seattle structural genomics center for infectious disease]] | ||
[[Category: Ssgcid]] | [[Category: Ssgcid]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 08:02, 10 October 2013
Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Burkholderia xenovoransCrystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Burkholderia xenovorans
Template:ABSTRACT PUBMED 23382856
FunctionFunction
[Q13VL5_BURXL] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).[HAMAP-Rule:MF_01815]
About this StructureAbout this Structure
4dfe is a 4 chain structure with sequence from Burkholderia xenovorans lb400. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D 3rd, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC. Combining functional and structural genomics to sample the essential Burkholderia structome. PLoS One. 2013;8(1):e53851. doi: 10.1371/journal.pone.0053851. Epub 2013 Jan 31. PMID:23382856 doi:http://dx.doi.org/10.1371/journal.pone.0053851